Parkinsonism and motor neuron diseases: Twenty‐seven patients with diverse overlap syndromes
Identifieur interne : 000596 ( Main/Exploration ); précédent : 000595; suivant : 000597Parkinsonism and motor neuron diseases: Twenty‐seven patients with diverse overlap syndromes
Auteurs : Rebecca M. Wolf Gilbert [États-Unis] ; Stanley Fahn [États-Unis] ; Hiroshi Mitsumoto [États-Unis] ; Lewis P. Rowland [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-09-15.
English descriptors
- KwdEn :
Abstract
It has long been recognized that signs of motor neuron disease (MND) may accompany clinical evidence of parkinsonism in different neurodegenerative conditions. By using the Columbia University Division of Movement Disorders database, we reviewed data from 5,500 cases of parkinsonism and recorded the presence of upper motor neuron (UMN) dysfunction, lower motor neuron (LMN) dysfunction, or both. Among the 27 patients so identified, we counted those with autonomic dysfunction, cerebellar dysfunction, or dementia. Among the 27 cases, seven had UMN signs and LMN signs as well as parkinsonism and were diagnosed with amyotrophic lateral sclerosis (ALS)‐parkinsonism (Brait‐Fahn disease). Three of the seven had dementia that was not deemed to be frontotemporal dementia (FTD). Six other patients had no LMN signs but had UMN signs and parkinsonism and were classified as having primary lateral sclerosis (PLS)‐parkinsonism. Four patients had both UMN and LMN signs with parkinsonism as well as the characteristic dementia of FTD; they were diagnosed with FTD‐parkinsonism‐ALS. Seven patients had MND, parkinsonism, and autonomic or cerebellar dysfunction, a combination compatible with multiple system atrophy (MSA). Three patients had syndromes compatible with hereditary spastic paraplegia (HSP). In sum, we found that MND occurs in association with diverse parkinsonian syndromes; some are heritable, others sporadic and causes are uncertain. Having MND may be a risk factor forparkinsonism. A prospective study may elucidate this possibility. © 2010 Movement Disorder Society.
Url:
DOI: 10.1002/mds.23200
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Parkinsonism and motor neuron diseases: Twenty‐seven patients with diverse overlap syndromes</title>
<author><name sortKey="Gilbert, Rebecca M Wolf" sort="Gilbert, Rebecca M Wolf" uniqKey="Gilbert R" first="Rebecca M. Wolf" last="Gilbert">Rebecca M. Wolf Gilbert</name>
</author>
<author><name sortKey="Fahn, Stanley" sort="Fahn, Stanley" uniqKey="Fahn S" first="Stanley" last="Fahn">Stanley Fahn</name>
</author>
<author><name sortKey="Mitsumoto, Hiroshi" sort="Mitsumoto, Hiroshi" uniqKey="Mitsumoto H" first="Hiroshi" last="Mitsumoto">Hiroshi Mitsumoto</name>
</author>
<author><name sortKey="Rowland, Lewis P" sort="Rowland, Lewis P" uniqKey="Rowland L" first="Lewis P." last="Rowland">Lewis P. Rowland</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:7C83527D711E75B3604D4B60C7490EC5DD3EA55C</idno>
<date when="2010" year="2010">2010</date>
<idno type="doi">10.1002/mds.23200</idno>
<idno type="url">https://api.istex.fr/document/7C83527D711E75B3604D4B60C7490EC5DD3EA55C/fulltext/pdf</idno>
<idno type="wicri:Area/Main/Corpus">001188</idno>
<idno type="wicri:Area/Main/Curation">000F89</idno>
<idno type="wicri:Area/Main/Exploration">000596</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Parkinsonism and motor neuron diseases: Twenty‐seven patients with diverse overlap syndromes</title>
<author><name sortKey="Gilbert, Rebecca M Wolf" sort="Gilbert, Rebecca M Wolf" uniqKey="Gilbert R" first="Rebecca M. Wolf" last="Gilbert">Rebecca M. Wolf Gilbert</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, NYU Langone Medical Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fahn, Stanley" sort="Fahn, Stanley" uniqKey="Fahn S" first="Stanley" last="Fahn">Stanley Fahn</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Columbia University Medical Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mitsumoto, Hiroshi" sort="Mitsumoto, Hiroshi" uniqKey="Mitsumoto H" first="Hiroshi" last="Mitsumoto">Hiroshi Mitsumoto</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Columbia University Medical Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rowland, Lewis P" sort="Rowland, Lewis P" uniqKey="Rowland L" first="Lewis P." last="Rowland">Lewis P. Rowland</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Columbia University Medical Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2010-09-15">2010-09-15</date>
<biblScope unit="volume">25</biblScope>
<biblScope unit="issue">12</biblScope>
<biblScope unit="page" from="1868">1868</biblScope>
<biblScope unit="page" to="1875">1875</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">7C83527D711E75B3604D4B60C7490EC5DD3EA55C</idno>
<idno type="DOI">10.1002/mds.23200</idno>
<idno type="ArticleID">MDS23200</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>amyotrophic lateral sclerosis</term>
<term>frontotemporal dementia</term>
<term>motor neuron disease</term>
<term>multiple system atrophy</term>
<term>parkinsonism</term>
<term>primary lateral sclerosis</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">It has long been recognized that signs of motor neuron disease (MND) may accompany clinical evidence of parkinsonism in different neurodegenerative conditions. By using the Columbia University Division of Movement Disorders database, we reviewed data from 5,500 cases of parkinsonism and recorded the presence of upper motor neuron (UMN) dysfunction, lower motor neuron (LMN) dysfunction, or both. Among the 27 patients so identified, we counted those with autonomic dysfunction, cerebellar dysfunction, or dementia. Among the 27 cases, seven had UMN signs and LMN signs as well as parkinsonism and were diagnosed with amyotrophic lateral sclerosis (ALS)‐parkinsonism (Brait‐Fahn disease). Three of the seven had dementia that was not deemed to be frontotemporal dementia (FTD). Six other patients had no LMN signs but had UMN signs and parkinsonism and were classified as having primary lateral sclerosis (PLS)‐parkinsonism. Four patients had both UMN and LMN signs with parkinsonism as well as the characteristic dementia of FTD; they were diagnosed with FTD‐parkinsonism‐ALS. Seven patients had MND, parkinsonism, and autonomic or cerebellar dysfunction, a combination compatible with multiple system atrophy (MSA). Three patients had syndromes compatible with hereditary spastic paraplegia (HSP). In sum, we found that MND occurs in association with diverse parkinsonian syndromes; some are heritable, others sporadic and causes are uncertain. Having MND may be a risk factor forparkinsonism. A prospective study may elucidate this possibility. © 2010 Movement Disorder Society.</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>État de New York</li>
</region>
</list>
<tree><country name="États-Unis"><region name="État de New York"><name sortKey="Gilbert, Rebecca M Wolf" sort="Gilbert, Rebecca M Wolf" uniqKey="Gilbert R" first="Rebecca M. Wolf" last="Gilbert">Rebecca M. Wolf Gilbert</name>
</region>
<name sortKey="Fahn, Stanley" sort="Fahn, Stanley" uniqKey="Fahn S" first="Stanley" last="Fahn">Stanley Fahn</name>
<name sortKey="Mitsumoto, Hiroshi" sort="Mitsumoto, Hiroshi" uniqKey="Mitsumoto H" first="Hiroshi" last="Mitsumoto">Hiroshi Mitsumoto</name>
<name sortKey="Rowland, Lewis P" sort="Rowland, Lewis P" uniqKey="Rowland L" first="Lewis P." last="Rowland">Lewis P. Rowland</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000596 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000596 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonV1 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:7C83527D711E75B3604D4B60C7490EC5DD3EA55C |texte= Parkinsonism and motor neuron diseases: Twenty‐seven patients with diverse overlap syndromes }}
This area was generated with Dilib version V0.6.23. |